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Baclofen or gabapentin for LPR

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Posted 11/3/2012 5:20 AM (GMT 0)
Has anyone had experience with this?

gabapentin or baclofen.

Post Edited (kevinla) : 11/3/2012 9:41:48 AM (GMT-6)

Posted 11/3/2012 2:19 PM (GMT 0)
If your asking can you take Baclofen and gabapentin (Neurontin) together - this is a question for your Dr. as they both have have central nervous system activity.

Baclofen is a muscle relaxer and an antispastic agent.

Gabapentin is used to treat partial and secondarily generalized seizures. It is legal (and common) to prescribe medicines for “off-label” uses even though the FDA has not formally approved such uses. So gabapentin is often used off-label for many types of pain, most often the pain of diabetic neuropathy, as well as for some mood disorders, such as anxiety. In fact, more people take gabapentin to treat pain than to control seizures.

Not sure in what context your question is meant ?  Where does it connect to GERD for you ?

Please remember, I am not a Dr.

 

Posted 11/3/2012 3:42 PM (GMT 0)
I was not clear. Some patients have been prescribed these medications for LPR like symptoms.
Posted 11/3/2012 4:51 PM (GMT 0)
Would love to hear anecdotes about either for LPR too.
Posted 11/4/2012 12:07 AM (GMT 0)
I was prescribed them by an ENT. In my case, I do not think they made any difference and I wouldn't think they would make any difference. Baclofen decreases TLESRS...

My ENT claimed that transient lower esophageal sphincter relaxations are the #1 cause of reflux. That may be true, but I bet decreasing TLESRS would help heartburn patients much more than LPR patients. There is a subset of GERD/LPR patients called "isolated upright refluxers" where it's believed that the LES becomes 'patulous' and allows a squirt of aerosolized reflux.

So in the case of upright refluxers, it's not the TLESR that causes the reflux, it's the shape of the LES/GEJ in the upright position.

Anyways, baclofen didn't work for me.

Gabapentin, I'm not sure if it decreases TLESRs. I think it's used mostly as a pain modulator, when someone is having symptoms with "physiologic" levels of reflux. Though I would say it's hard for a dr. to say when a patient has pyhsiologic/normal amount of reflux due to the insensitivity of certain tests. A regular PH study with sensors in the distal and proximal esophagus is not enough, a sensor is needed above the upper esophagus if one hopes to detect LPR-related reflux.
Posted 11/14/2012 8:00 PM (GMT 0)

drtinsac said...
There is a subset of GERD/LPR patients called "isolated upright refluxers" where it's believed that the LES becomes 'patulous' and allows a squirt of aerosolized reflux.

So in the case of upright refluxers, it's not the TLESR that causes the reflux, it's the shape of the LES/GEJ in the upright position.

To my knowledge, tLESRs are the primary mechanism of reflux in all reflux. Can you please share the research that suggested an alternative mechanism of reflux in LPR?
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