I had severe side effects on ranitidine: joint pain, nausea, stomach pain, etc. Protonix made my throat feel like it was swelling. Am now on Nexium. Unforrtunatley, I don't think these side effects are as 'rare' as the insert claims. Each person reacts differently, if one isn't working for you try another. My friend has very good luck with Prevacid. I hope you feel better soon!