Does increasing acid production also increase pepsin?

I have LPR. I have a feeling, but can not be certain, that bile reflux and or pepsin is the culprit. I do not believe I have acid reflux, but I can not be certain.

I do not have any heartburn or stomach issues. Just throat issues.

I am beginning to take a herbal formula called Trikatu. It is a digestive stimulant consisting of equal parts ginger root, black pepper, and long pepper, used to aid digestion.

It says on the label ".....not recommended for people with acid reflux or hyperacidity."

Trikatu is supposed in increase acid production.

Will increasing acid production also increase pepsin? I found this information about the creating of pepsin.

Somebody said...
Pepsinogen is an inactive enzyme secreted by the gastric glands. It is converted into pepsin in the stomach through the presence of gastric acid known as hydrochloric acid. The main function of pepsin is to digest protein.

Post Edited (kevinla) : 7/21/2013 6:55:55 PM (GMT-6)

mattinthehat2502 said...
I don't believe that increasing acid increases the amount of pepsin. My understanding is that it increases the activity of the pepsin that is already there. Pepsin can be active all the way up to pH 7, but the higher the pH the less active it is. Thus, a refluxate with pH 3 would have pepsin more active than a refluxate with pH 6, for example. This is just what I have understood from reading, I am not a doctor.

Then I need to rephrase my question.

If acid increases the activity of the pepsin and pepsin is the cause of my throat issues will taking the Trikatu exacerbate my throat symptoms?