Lynne: You may see this twice... I typed out a reply which "disappeared"... good old computers!! (*_*) Anyhow, my doctor told me to take Nexium one hour before the largest meal of the day... for me that is supper. Sometimes I forget and end up taking the pill a few minutes before I eat... so far, no dire results from that. There are also times that I forget entirely, but I have never missed more than one day. If I do forget, I just take one the next day before supper. He also said if you're have a "flare up" to add an over the counter antacid an hour after the meal...and more, as needed, until you are "calm" again. This has worked well for me. Good luck!.... Jeanne