New study says patients who can't tolerate PPIs may benefit from SSRIs.

Alcie

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Joined : Oct 2009

Posts : 5200

Posted 6/20/2011 11:10 PM (GMT 0)

In an article reported on in Reuters (I read it in Medscape) it was noted that some patients with NERD (non-erosive reflux disease) with typical reflux symptoms have hypersensitive esophagus. Citalopram (Celexa), an antidepressant was effective vs placebo in relieving GERD symptoms in the small study.

mudmagnetmum

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Joined : Apr 2011

Posts : 1605

Posted 6/22/2011 3:57 PM (GMT 0)

Thanks for this info
http://www.medbioworld.com/news.php?topic=0&article=20110610clin004.xml
When you read through it looks like they mean patients for whom ppis do not work, rather than patients who cannot tolerate the ppi drugs, but it is interesting. I have wondered whether the constant acid reflux means we all have some hypersensitivity of the oesophagus. The article also made me wonder if St John's Wort would help some people, but I'm not sure about taking it alongside ppis. The herb can cause sun sensitivity, as do ppis, so possibly not a good idea to combine that particular side effect. If I ever get properly off ppis I might try St John's Wort!

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