Posted 12/28/2017 7:21 PM (GMT 0)
I have experience with Baclofen. I've been using it off and on for about 9 months for GERD.
It works very well, and I'm surprised more people don't know about it. To be honest, I had really bad reflux on the morning I had my graduate thesis presentation, and baclofen helped me really tremendously at that time. I'm prescribed 10mg pills, and I usually just take a bite out of the pill, so I only take in 2 or 3 mg's. Basically, it doesn't technically "tighten" the area, but it prevents TLESR (transient lower esoph. sphincter relaxations).
It would probably be a miracle drug if it didn't have side effects, which you don't always get. Generally, it may make you tired, so that's one thing to consider...But, once in a while (not all the time), the drug may give you nausea, so you have to be careful with that, and maybe keep some zofran on hand. It's interesting because I read that they were trying to make some kind of derivatives of this drug, that would still be effective, but without the side effects. I don't think they were successful though yet.
I would advise to use this ONLY when you really need it, and as a second line defense against reflux, when PPI's/H2's are not working. If you do that, then this drug will probably be effective for you.
TLDR: it works well, but use it only for really bad symptoms, when the other stuff doesn't work.