Psoriatic Arthritis and Humira

This is my first ever entry in a forum of any kind.  I have had PA for several years and the arthrits was controlled very well with methotrexate.  Unfortunately I developed adverse reaction to methotrexate after taking it for about 10 years and had to discontinue its use.  After various trials of less effective meds, my rheumatologist put me on Humira.  I have been on Humira for 3 months now and the arthritis has calmed down dramatically (I remain on anti inflamitories).  However, the psoriasis seems to be flaring up.  I thought the Humira would help eleviate the psoriasis as well.  I wonder if anyone else has had this experience.

Like you, I was on MTX for psoriasis and PsA until I ran into problems, in my case liver enzymes. And like you, I ended up on Humira, which I've been on for two months.

On MTX, I had no psoriasis at all, but I did have consistent problems with yeast and fungus. When I started Humira, I had been off MTX for 3 months and my psoriasis was getting steadily worse. Then after my first dose of Humira, my psoriasis flared dramatically. It was also my first ever bout of pustular psoriasis, which is just as nasty as it sounds. My dermatologist declared this a coincidence, unrelated to Humira. She gave me a new (to me) topical, ProTopic, which worked very quickly, despite not having a steroid.

After two months, I think I'm making good progress on the joint pain with Humira, but the psoriasis doesnt seem to be improving as much. MTX cleared my psoriasis in just a few weeks. For me, biologic therapy works more slowly than MTX, but I haven't had any side effects from it, while MTX caused some real problems for me. I'm still very hopeful about the Humira.