Through my own experience with being Housebound Agoraphobic,I have learned it is unhealthy to stay in all the time.
The past 5 + Years,I haven't gotten adequate fresh Air,Sunlight or physical activity.
After awhile staying indoors starts working on our Immune System and affects our Joints.I say this from personal experience.
I've noticed the tendency to have Chest Colds/Cough that quiet possibly turns into Bronchitis or even Walking Pneumonia.
Though SOB (Shortness of breath) and the feeling we're suffocating is a symptom of Anxiety/Panic,I have been really bad to suffer which in turn creates MORE Anxiety.
Staying in constantly we breathe in dust,dust mites,mold/mold spores etc even if we dust every other Day.
I most definitely can tell I haven't done enough walking because I become extremely sore when I do get out.
Just wanted to add my 2 Cents which may not be much