wxman,
Hey there.
Yes, natural antidepressants can interact with prescription drugs. Combining natural antidepressants and precription drugs may either weaken the effect of the drug, or increase the side effect. I would look it up before taking it together.
I too haven't been doing well the past few weeks. Lots of unwanted stress.
What is your diet like? I know a lot of people ignore their diet and do not believe that what they eat and drink will affect their condition. You can also make some changes in your diet too.