Definitely!
P/a has affected every relationship I have or had. My husband is amazingly supportive, but it still creates problems when he wants to go to his family get togethers and I don't feel up to it, he gets angry because he thinks his family doesn't understand and he gets embarrassed that I'm not there, although for the most part they do understand. If I force myself to go I feel very resentful toward him, so it's a tough situation all around.
Of the 8 kids in my family, only one still talks to me and she is the one who lives in another state. I have 3 sisters who live within 25 minutes of me and I never see or hear from them. We all used to be so close and then the p/a started and everyone kind of bailed on me. It's all just to inconvenient for them.
I don't have any friends, but that I think is mostly due to my insecurities, but the difficulties of people not understanding what I go through and not being able to go out shopping or to lunch with them isn't very conducive to keeping up a friendship either.
I think being "dumped" by my family has caused me to be way to cautious about making any friends, so I just don't even try.