ADVICE? TREATING COMT V158M COMT H62H MAO-A R297R

I have recently received 23andme results. Its so overwhelming on where to begin! I have a long history of anxiety, stress and brainfog, although I have a high IQ. Does anyone out there have experience in this? What supplements are recommended? I picked out the main offenders... looking to treat the following mutations:

HOMO:
COMT V158M AA
COMT H62H TT
MAO-A R297R TT

Any help at all would be VERY greatly appreciated! THANKYOU

Thanks for your kind words of support, its nice to know i'm not alone. As for ports of call i've already been down that road... Dr's, Psychologists, Psychiatrists, therapies including CBT... all with little help or shown me options I know will not do me any favours in the long run. Most of the information i've gathered has been from doing thorough research on myself. Ive found nutrition and exercise to be the most beneficial but they only go so far.

Clearly I have been passed on some major SNPs associated with neurological issues. I'm interested in balancing my methylation pathways and reducing inflammation but unsure what supplements to take for which SNP? Theres alot of information out there and its hard to trust which sources are reputable. I was just interested to know if anyone had similar SNPs to me and how they treated them.

Also thanks i will check out the resources thread.

My 23andme results just came out and I have a similar genetic profile [although I think mine is much worse]

Can anybody look into this or at least recommend me a place that could help me to get help with the associated conditions


These are my homozygous mutations:

Methylation Profile:

COMT V158M
COMT H62H
VDR Taq
MAO A R297R
MTRR A664A

Detox Profile:
SOD2 A16V
NAT2 R197Q

thanks

Hi

Welcome to the forum.

I don't know much about this so can't really offer any specific support but hopefully we have some members that can.

Hibee

Thanks for this forum! (newbie here)

Well, It's your Lucky Day, Folks! There's always someone worse off, right? Well, today I get the prize. Lol! I have done 23andme and then used the Variant Report ($30) at https://mthfrsupport.com/order-reports/

https://mthfrsupport.com/2016/05/what-sterling-thinks-are-the-most-important-genes-on-the-variant-report-to-date/

OR some people have used this $19. Report generator (but I haven’t, so I can’t comment on it) https://livewello.com/genetics

Once you upload 23andme raw data and then run through an online 'interpreter', download the PDF, then you can search web, including SNPedia. HUGE amount of info.

https://snpedia.com/index.php/SNPedia

The mthfrsupport variant report breaks snps down into categories: Liver Detox, Mitochondria, Methylation, Neurotransmitter, Gluten Intolerance and much more. (FYI, geneticgenie.org only gives methylation and detox info, but it's free).

I am copying a SNP from my variant report and then searching for it in SNPedia and online (starting with my homozygous mutations). The Sterling variant report online has great charts, so you can see which gene affects which parts of each cycle (methylation, detox pathways, etc.)

I am also searching for a Functional Medicine Dr. and/or someone that works with genetic info. I have many symptoms (won't go into that now, yet depression and anxiety are among them. FYI: epsom salts bath/magnesium is great for mitigating panic attacks!). But for now, the online info is much more affordable than working with a professional (but it is laborious, and I am limited in what I can really do, in so far as being certain that what I try is what I should try- see below).

I am currently on a Methylation Support (methyl B vitamins) product (sublingual 2x per day) for MTHFR hetero MTHFR A1298C. I think I need to get a SAM (SAM-e) supplement (for all my COMT homo mutations). Probably should have done that first, but...oh, well. Will post updated info as I find out what is correct (for me). I also wish to consult with my local compounding pharmacy (People's in Austin- evidently they counsel on 23andme raw data)

I know I need to address the biggies: homo G6PD, COMT, MAO, CBS, GAD, BHMT, VDR Bsm, AGXT (and others) and my MTHFR and FUT2 (even though they are hetero). I am trying to eat 4-6 cups of high folate foods: dark leafy greens (kale, spinach, arugula) along with asparagus, broccoli, sprouts, peas, lentils, avocado, et al) a day, but I also need to research mitigating factors like: my CBS homo mutations and sulfur and oxalic acid (and my homo AGXT genes), so I’m going really light on the onions, garlic, spinach, Brussels, etc. (SO hard to not eat these foods! So, I’m going to research all that soon).

http://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/

http://www.jillcarnahan.com/2014/02/23/health-tips-for-anyone-with-a-mthfr-gene-mutation/

https://livewello.com/


Here are my homozygous (double) mutations:

G6PD, COMT, MAO, CBS, GAD, BHMT, VDR Bsm, AGXT (and others)

and my Hetero mutations: MTHFR and FUT2

FYI, I have tested super high for heavy metals (lead, mercury, aluminum, cadmium and many more), so I had my amalgam filings safely removed (in 2008, using a strict protocol), and I've been going through heavy metal EDTA IV chelation since 2008 (off and on, probably about 40 sessions- I should go 1-2 times per week, but it takes energy and money. Sadly, I have neither.). BUT, since I was only diagnosed with the MTHFR and only on methylation support for last several months, the IV chelation doesn't seem to have been successful. I am hoping now that I am on methylation support I will soon (this year?) see better progress on ridding my body of the toxic heavy metals.

Thank you in advance to adding to this conversation. I look forward to sharing info/experience in what works/what doesn't as we all gain it.