This is about treatments for Metastatic Castrate Resistant Prostate Cancer (mCRPC). There is currently a whole list approved drugs (Jevtana, Novantrone, Provenge, Taxotere, Xofigo, Ztandi, Zytiga)...
I read the following article: Prognostic model predicting metastatic castration-resistant prostate cancer survival in men treated with second-line chemotherapy, by Susan Halabi, et al., October 17,...
Allen, Actually there were a few more drugs available before 2004: Diethylstilbestrol (DES, available since 1941). Orchiectomy or DES or both were the standard initial treatment for symptomatic...
http://www.ncbi.nlm.nih.gov/pubmed/24053150 is the title of a recent publication which took my attention. We tend to look at successes but the failures are more abundant. Their conclusion:...
Casey: From a 1998 publication: 'Ketoconazole should no longer be prescribed for relatively mild cosmetic disorders such as onychomycosis' (fungal infection of the nail). In a more recent review...
European Medicines Agency recommends suspension of marketing authorisations for oral ketoconazole. http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2013/07/WC500146613.pdf...
Buddy Blank: international guidelines for the use of granulocyte colony-stimulating factor (G-CSF). Recommended when the overall risk of febrile neutropenia is ≥20%. Tall Allen: Thank you very much...
although my white blood cell counts were down, especially my lymphocytes, due to the (oral) chemo I was using. I had to stop the treatment while my PSA was still going down. Normally the relationship...
Sorry, I see there was already a post on Xofigo....
Good news: "Bayer Receives U.S. FDA Approval for Xofigo ® (radium Ra 223 dichloride) Injection as a New Treatment for Castration - Resistant Prostate Cancer with Bone Metastases. The approval of...
Moreover, Overall Survival (OS), I prefer to think of it as Time To Death (TTD), is not so relevant anymore for docetaxel. When it failed there are several other drugs, such as cabazitaxel (Jevtana),...
Sorry, Allen, I had not looked at the 'treatement-related' deaths (might be somewhat difficult to decide if it is PCa-related, or so-called co-morbidity, or treatment-related). But, even with the...
Statistics ! On 1050 patients in the trial 1 patient died in one branch, 4 in the other one. Yes, 4-fold higher, but how many can you expect beforehand ? And the 35% increase of serious SEs: it...
Failed miserably ? Addition of Avastin increased the median Overall Survival from 21.5 to 22.6 months, the median Progression Free Survival from 7.5 to 9.9 months, and the Objective Response from...
Tall Allen: Press Release, November, 22, 2011. Celgene International Sàrl, a subsidiary of Celgene Corporation, (NASDAQ: CELG) announced that based on the recommendation from the Data Monitoring...
It is Avastin (bevacizumab). A slide-presentation about Zytiga (by Janssen Biotech/Johnson & Johnson), which I saw on the internet, contained a slide with a graph that had on the vertical axis the '...
I came across Dostinex in a presentation by dr. Meyers on www.HRPCA.org: A Presentation by Charles E. Myers Jr., M.D. to the Kettering Medical Center Prostate Cancer Support Group on April 25, 2002...
I have bone mets too (from face to legs). When I was in the same situation as you are now, that was 2 years ago, the late David E. gave me the advice to look into 2nd-line hormone treatments in stead...
Last year I was looking into starting a small business and retire from high-tech (ie high stress) work but as a business owner I'd have to pay something $1750 per month to cover just myself. I now...
Last Friday I had my 36th 4-weekly Zometa infusion, at 2.8 years after being diagnosed with (bone-)metastatic PCa. My oncologist asked me if I should not reduce the frequency to once per 8 or 12...
As dr. Tannock said: the modest gain in median survival (2-3 months) obtained with docetaxel needs to balanced against the side-effects and cost of the treatment. And actually, the claim of a longer...
Did anybody listen ? In the TAX327 trial 1006 patients with metastatic hormone-resistant PCa were treated with docetaxel (Taxotere, Aventis) or mitoxantrone (Novantrone , Immunex and Wyeth-Ayerst)...
In France, it is called distilbene, and it sells 26 tablets for 13.84 euro. My pharmacy could order it from there (I am not living in France). There is just a 1 mg tablet. There have been reports...
In a recent post somebody made this statement. I wonder if the following has something to do with it. As an example, there is a drug, sargramostim (marketed by Genzyme under the tradename Leukine)...
I just read the collaborative review about Castration-Resistant Prostate Cancer (CRPC) by urologists and oncologists from the USA (5), Canada (3), United Kingdom (1) and Italy (1), published online...
A reduction by 66% with Taxotere is actually a quite good response for this chemo. DES (diethylstilbestrol) is known to be effective after this chemo (David E., for example, got about 85% reduction...
I saw this mentioned in the John Hopkins Prostate Bulletin (don't know the issue anymore): "Important prostate issues to consider if you're contemplating testosterone replacement therapy. The good...
What about 'units-of-measure' ? You might find nmol/l in stead of ng/dl. 1 nmol/l = 29 ng/dl. (testosterons molecular weight is 288.43 g/mol). Normal range of testosteron is 250 to 800 ng/dl, but...
With 3 monthly Zoladex my T actually went down as low as 9 !...
Piano, what I don't understand is that nobody here ever tried something from dr. Leibowitz's protocol which he has been using for more than 10 years (see his reports of the Compassionate Oncology...
I once read, don't have the reference anymore, that for a real large number of men, I think it was over 100,000, their average PSA was 1.06. Depending on age: the 40-year old ones had 0.7, and for...
I must admit: I was very sceptical when my oncologist offered me as the next drug 0.1 mg (!) ethinyl estradiol (EE). Was this tiny amount going to work, and also, didn't somybody like Leibowitz for...
Medved, I went to a cancer institute for a 2nd opinion. The oncologist there believed in chemo only. Okay, he had also available a phase-3 clinical trial in which this chemo is to be combined with an...
So I am castrate-resistent and needed another therapy. David told me not to go for the chemo, but look into a 2nd-line hormonal therapy first. The Taxotere (docetaxel) chemo has a poor response...
The Johns Hopkins Prostate Bulletin brings you eye-opening reports about new therapeutic avenues. . . advance news of clinical trials in which you can participate. . . detailed answers to...
So how costly would this be ? I know they charge $750 per hour. But a 4 months treatment by dr Leibowitz, how much would that amount to ?...
http://www.jurology.com/article/S0022-5347(08)03053-X/abstract I just find out about this report, and I find it incredibly important. Intermittent androgen deprivation (IAD) therapy until now (see...
One week before my first shot of Zoladex I got Cyproterone acetate (brandnames: Androcur, Cyprostat,Cyproteron, Procur, Cyprone, Cyprohexal, Ciproterona, Cyproteronum, Neoproxil, Siterone). And...
I saw an interesting article http://www.jurology.com/article/S0022-5347%2808%2903053-X/abstract where hormone therapy was combined with thalidomide in an intermittent treatment: on-period 6 months...
Chadhas, I know somebody with bone cancer who had Zometa for 3 years. Then he got a jaw problem and stopped for a while. Now he is back on it. You will find somebody on this forum, FLHW (David E.),...
Worried Guy, I had not seen our family doctor for 30 years or so. Not even ever having a cold. Then in May, June '09 I felt less fit, and a month or so later I had pain in my upper left leg when I...
David, thank you very much for your advice. I have found a lot of information indicating that the 'standard' chemo's, such as taxotere, had very little effect on survival time, although it is a very...
Dear all. thank you for your supportive reactions and well-wishes. Until now I have only been seen our family doctor (a very supportive guy) and an urologist of the local hospital. I started to study...
and it kept me awake the whole night: I got the lab result of my July 9th blood sample, PSA = 5.7. Okay, my starting PSA, August last year, was 575, a lot higher. In September I got on HT and the...
There are labs which won't give a number below 0.1: they only report PSA <0.1, although they measure 2 decimals. Do you really want to know ?...
I am under HT, and personally have nothing serious. The first 10 weeks I had a lot of 'hot flashes', but that has become much less since. I have no incontinency, no erection problems. I feel fit and...
I have an acquaintance who has the same urologist as I do, and he is under AS. His PSA was as high as 9 three years ago and has now increased to 12. Still no problems. I should add that he is already...
Zoladex 10.8 mg (3 months) is €600, about US$819, delivered at home. Zometa (4 weekly) is €320, about US$437, and delivery at home is also included. We have a required basic health insurance, which...
I am currently on Zoladex+ 150 mg Casodex, and the Zoladex is injected once per 3 months, i.e. 13 weeks. About a week before my second and also before my third injection I had some bone pain (I had a...
Here in the Netherlands the 3-monthly Zoladex (10.8 mg) is 600 euro ($819), and we have a generic version of Casodex (bicalutamide), which is, for 150 mg/day, just 90 euro ($123) per month. The nice...