I am new to the forum and I was wondering about changing from mtx b/c of my weekends are being spent exhausted in bed. I know it is the mtx because I skipped a dose and felt like a normal person all week. I understand that my doctor is doing the best he can. But the fatigue is what is holding me back from getting on with my life - i.e. a job, a normal social life, and just enjoying life. I would love to not spend days sleeping off the side effects of mtx. - UGH! Or fall asleep during a conversation and wake up hours later. UGH, UGH Does anyone have suggestions on what to do about the fatigue?