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Enbrel and Methotrexate causing fever and horrible fatigue

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Rheumatoid Arthritis
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Posted 6/20/2012 9:55 PM (GMT 0)
I'm taking MTX and Enbrel and I take the two on the same day..lately I have been having fevers to the point I am sweating and the fatigue is so bad all I want to do is sleep.  I'm wondering how many take MTX along with the biologics? I don't feel well at all, and I'm wondering if it is too much with the two together..anyone else feel this horrible with both?

Thank you in advance!

Posted 6/21/2012 12:07 AM (GMT 0)
Maybe try them on separate days since they are both strong medicines?
Posted 6/21/2012 4:15 PM (GMT 0)
Of course, every "body" is different. I agree with Joy to try them on different days. How long have you been on each med? That may make a difference, especially if you are "new" to Enbrel.   On purpose, I would inject Enbrel on a Thu and take MTX on a Monday, however with my crazy schedule (and my aversion to needles), I ended up forgetting to take my Enbrel dose on each Thu so as time progressed, I ended up with my current schedule: I take them both (MTX and Enbrel) on the same day (Tue). For me, I don't see any difference if I take them together or apart but again, my body is not yours. Please try to space them out. And of course, keep your rheumy informed of your dosage days and a record of how you feel. Hopefully the combo is making your join pain subside.   Debbie
Posted 6/21/2012 5:32 PM (GMT 0)
 

I'm sorry that you are feeling so bad Momto3. :(  I know it is particularly difficult when we have Kids to look after. 

I was on MTX with all the biologics I was on but didn't specifically take them both on the same day.  I haven't felt bad fever wise with the two meds combined.  I'm recently off MTX now because it's not needed with Actemra after it's kicked in plus I had bad ulcers on my tongue.

Low-grade fevers can be a symptom of RA.  Having said that, you sound like you have a higher fever?  We are prone to infections. 

Just a shot in the dark but hopefully and most likely it's not your case.  I ended up with blood poisoning one time because I had a UTI that I barely noticed.  I got anti-biotics which evidently didn't work.  Later, achy kidneys, high fever, nausea, chills, exhaustion(collapsed on the floor).  I felt terrible.  My Hubby found me and called 911.  They started me on oral anti-biotics and 2 IV antibiotics plus another anti-biotic for when I went home.  They said I was lucky that my Hubby found me and that I made it to the hospital.  I DO agree.

I sure hope that you are feeling better today Mom.  If not please seek help from your Dr.

Posted 6/22/2012 12:29 AM (GMT 0)
Sorry you're feeling so bad Momto, I haven't heard of fevers with meds either but with us anything is possible.

I'd call your rheumy and ask, or you could try taking them on different days and see if it makes a difference. Try the embrel 1 day earlier and the mtx one day later. With lots of water in between.

Sounds a bit wierd to me though. You're not sick? No temps any other time?

Best wishes, golitho

Posted 6/22/2012 4:52 AM (GMT 0)
 

This may be over-reacting on my part but it says:

Tell your doctor right away if you develop symptoms such as unusual lumps/growths, swollen or painful abdomen, unexplained weight loss, persistent fever or night sweats.

 

Bottom part of the 2nd paragraph in the Enbrel Warning section near the top of page.  You didn't mention night sweats but....

http://www.webmd.com/drugs/drug-16772-Enbrel+SubQ.aspx?drugid=16772&drugname=Enbrel+SubQ

Sure hope that you are doing okay Momto3.

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