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Methotrexate stopped working ?
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Rheumatoid Arthritis
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Goughy12345
New Member
Joined : Sep 2014
Posts : 14
Posted 9/6/2014 3:32 PM (GMT 0)
I started methotrexate 4th June 15mg (6 x 2.5mg tablets per week) . it took roughly 2 months to take effect and for about
a week or 2 fingers were back to normal-ish. Since then they have gradually been going back to the way they were before starting the medication eg. stiff, swelling and painful. im finding it really difficult to clench a fist and cant grip heavy things without dropping them.
anybody else had this happen and what did you do/change?
specialist nurse said if these didn't work it looked like starting the biological stuff.
Carole_D
Regular Member
Joined : Sep 2013
Posts : 190
Posted 9/7/2014 12:33 AM (GMT 0)
I had a similar problem and my rheumy added meds. Apparently mtx works well with other drugs. First we tried sulfasalazine and tthen Enbrel. Now I'm taking mtx and Humira. So far it seems to be helping.
Goughy12345
New Member
Joined : Sep 2014
Posts : 14
Posted 9/7/2014 4:31 PM (GMT 0)
Is humira injected or is it tablet form??
My fingers are always worse first thing in a morning generally getting abit better throughout the day although never fully being pain free. I believe humira cant be used if you have liver problems ? And although i never have sincey last blood test i have got elevated liver levels. I m having another blood test tuesday to see of they have come down or not. So if they haven't i think i will probably be taken off mtx but not 100%. I will ask my rheumatologist about
humira though so thanks for your reply :)
Carole_D
Regular Member
Joined : Sep 2013
Posts : 190
Posted 9/7/2014 5:44 PM (GMT 0)
Humira is an injection. I asked for the autoinjector - it's an opaque plastic tube so you don't see the needle.
I don't know about
taking it if you have liver problems, but my rheumy has been monitoring my liver and kidney levels all along.
Good luck. I hope you find something that helps you.
Goughy12345
New Member
Joined : Sep 2014
Posts : 14
Posted 9/8/2014 10:25 AM (GMT 0)
does it hurt when its injected?
I have done some research and it wont be given if you have liver problems :/
which I don't normally have, its just since I have been on methotrexate so hopefully ill find out after 10th Sept if its gone back to normal or not.
thank you.. I wish you well too.
Carole_D
Regular Member
Joined : Sep 2013
Posts : 190
Posted 9/8/2014 4:26 PM (GMT 0)
It hurts a little when injected, but I ice the area for a few minutes and that helps. I figure pain for 1 minute or so is better than the pain from RA!
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