I was wondering if anyone had any bad side effects from orencia? I took my first injection several days ago, and it seriously caused a full blown flare! Of course my rheumatologist is on vacation, and I'm afraid to take my next injection. I don't know what to do. I really think it made me worse! I'm now taking prednisone to calm things down. I was on humira for 13 years. It was a miracle drug fir me until this past winter when I became ill and had to go off it for a couple months. When I restarted it, it just didn't work. I then tried enbrel, but it didn't really work and caused injection site reaction s. I've heard that when one tnf blocker fails, chances are all the rest of them will too.