I'm sero-negative and have never had a positive RA factor. Plaquinil is wonderful and takes around 3 to 4 months to get the full benefit. When it does kick it, it can help with the pain and increase your energy level, at least it did for me. Do make sure you have had a baseline eye exam that is for plaquinil users. I took it for two years and then had to discontinue because it was damaging my vision. I really miss taking it!
I hope the plaquinil helps you!