Hello!
I was on Plaquenil for awhile until I became allergic to it. It helped a lot with fatgiue. I take MTX and Humira now, and my CRP levels are still too high. I also take Prednisone, Celebrex and Tramadol. I am much better than I was. Humira does help w/fatigue and it cut my CRP level by half, which is a good thing. I hope Plaquenil works for you. It is a fiarly safe med, or so they say, as far as RA meds go.
Blessings,
V