Plaquenil after meals

I know it's recommended to take plaquenil after meals because of the stamic iritation it can cause.
I am no affected by such iritation and so i dont take plaquenil after meals everyday.
What i wanted to ask is - does it make plaquenil less effective if it is not taken after the meals? does it matter somehow except for the stamic aches? thank you.

I take plaquenil for rheumatoid arthritis (I was actually diagnosed with sjogrens first, it's complicated!) and I've found I can take it with my morning coffee if there is half and half in the coffee. In fact on my prescription it says take with food or a glass of milk. I think having even just a bit of fat in your stomach (so not skim milk) is enough to avoid any problems.

Taking it with food definitely does not make it less effective.