My soon to be ex is exaclty like you described. As a BP person i have mentioned to her that she may be BP also. But she refuses to admit it. So i have no choice but to leave the relationship for my own health.
In the end we have to "own" this desease or it will completely own us. I was granted a moment of clarity by some higher power and that allowed me to find the peace i have today. People like your wife and my ex havnt come to grips with it yet, its our problem not theirs, they have done nothing wrong and refuse to even discuss there might be an issue.
In the end, unless she decides to take responsibility for this desease you have no choice but to leave her.
Bill