Fatigue after taking b-12 shot

Hi,

I'm visiting from the Lyme forum. I'm almost recovered (started treatment in Oct), but prior to my Lyme diagnosis, last July or so, I was having a lot a Chronic fatigue symptoms, especially after I took my B-12 shot. I have a clinically diagnosed B-12 deficiency and I take the shots once a month. Yesterday, I took my shot, but then developed some pretty bad fatigue. Does anyone experience this? I also have the MTHFR genes, so I take methylfolate and extra mag, potassium, other bs etc.. Any thoughts?

thx!

I have the MTHFR c677T mutation as well. What might be causing the fatigue is a detox reaction. When I first started taking the methylfolate and methylated b12, I would get overwhelming fatigue from getting my methylation cycle moving and functioning better. I could only take my vitamins 1-2 times a week and slowly build up. Now I take it every day without any detox symptoms. Since the shot is usually a high dose of B12, it probably moves your methylation quicker than what your liver can handle. It's best to slowly build up the vitamins to minimize the symptoms.

Cr3ativegirl.., i take a multi by Pure Encapsulations that has Folate (as Metafolin, L-5-MTHF) 400 mcg and Methylcobalamin 500 mcg. I'm getting 100% of Folate and 8333% of B12.