I was wondering if anyone has tried or is taking antidepressants. I think I have CFS. Most of my symptoms have gone away except for feeling really run down. I also have severe anxiety. I have been on Effexor XR, the lowest dose, and I have been feeling more tired and irritable and run down since taking this. My anxiety has also been getting worse. So I don't know if I am feeling so bad because the meds aren't working and the anxiety is causing this or if this is the CFS. Does anyone have only tiredness and run down feelings with CFS? When I feel really run down I feel dead and so far away. Can anyone relate? I have been sick for 7 months.