Anyone on Nucynta?

Just have to ask...why would your doc switch you to extended dilaudid AND nucynta?

Sarrah

I just got on it today. I take one 75 mg every 6 hrs. So I've taken two pills so far and my pain is about the same. It's too soon to tell. My PM doctor said if it works, it will work in two weeks (by the next follow up appt.) I've been told by him and the pharmacist that it IS stronger than Vicodin and more similar to the levels of Percoet and Tramadol.

I'll reply back in a few days to let you know if it is working for me.

Yes I have currently been on that medication going on 4 months. For me it has worked well until very recently. For the previous 3 months, my pain was at the moderate to moderate severe level and it DEFINATELY works better than vicodin, and is significantly stronger than tramadol. Its considered to equipotent to oxycodone's lower end of the pain relief scale, as it has relatively low side effects at lower doses (50, 75, 100), but moderately heavy side effects at 150-200. Reportedly, side effects aren't well tolerated beyond 200 mgs so there is a ceiling of use. It is similiar to tramadol, but its key differences are that it has stronger MOR receptor activation (opoid activity), stronger NE reuptake activity, but almost no SE reuptake activity (compared to tramadol). Its a single molecule thats active, so it doesnt have to be processed by the liver first to become active like tramadol and codeine do. It has less drug interaction and generally less side effects, but it does have a strong anti-depressant like effect. Medication can cause a stimulant like effect that turns into a more sedative like effect, but in general these side effects are managable.

The medication worked for 3 months with very little tolerance building for me. Whenever my pain was a 6 to 7, it did well to bring it down. Once my pain hit an 8 though, it just wasn't enough alone (though it still usually helped) and celebrex or ibu had to be used to help bring the pain down more. To me this medication is very useful because unlike percocet, it seems to build tolerance slower. However, percocet seems to take effect quicker. I personally believe the medication is slightly stronger than percocet overall in dose per dose comparison, and it seems to last slightly longer for pain relief. However, as I stated, its limited to treating moderately severe pain in my case and over the past several days ive been in the 8-9 pain scale region a few times, so its become less useful. I have an appointment with my PM doctor today, so we will see what he recommends, since this medication did work well for the most part.

PS- If your doctor recommends a trial of it, atleast try it out. Its lower risk of dependency coupled with its NE properties make it suitable for nerve pain (IMO)

i tried it and it caused significant sedation and a apathetic feeling and the pain reliving factor was not much. the FDA says it has a abuse profile similar to hydromorphone but i dont think so. i return most of the bottle to my doctor. it is new and the pharmacy reps are pushing it with percs to the doctors. it has a similar molecule to venlafexine [effexor] just like tramadol so it has the norepinerperine reuptake inhibition effect. it has only been approved for acute pain as far as i know.

Bob:
Thank You for taking the time to share your experience with Nycynta and, more importantly, your experience with adapting and adjusting to living with chronic pain - making the best of a less than ideal situation.

For me, the emotional aspects of living with unrelenting pain can be as taxing as the physical aspects. Pain is taxing, on many fronts.

Feel free to continue to post and contribute to this forum community. You are among friends here.
- Karen -