Actually, the variance is in the NON active ingredient. The US has some of the most strict laws on generics.
There can be a 20% difference in the "fillers" with which some people can have issues.
But just like with anything, people react differently to all sorts of meds, even over the counter things like Advil and Tylenol. It may work perfectly for one person but do nothing for another.
Case in point, whenever I use Benadryl, I get completely wired and feel like I've had lots of espresso! For many people, it makes them very drowsy.
I have the link below to the FDA website. I am truly not disputing the fact that people have their opinions and reactions to certain meds, just want people to have the information/facts about
the generics. The small variable of 3.5% is the accepted amount whether it's brand compared to brand or generic compared to generic/brand.
**Here are a few points from the site:
<ul type="disc" style="margin-top: 0pt;">
<li class="MsoNormal">Generic drugs are required to have the same active
ingredient, strength, dosage form, and route of administration as the brand name
product. Generic drugs do not need to contain the same inactive ingredients as
the brand name product.<span style="font-size: 11pt;"> <span style="font-size: 11pt;"> </li></ul>
<ul type="disc" style="margin-top: 0pt;">
<li class="MsoNormal">The generic drug manufacturer must prove its drug is the
same as (bioequivalent) the brand name drug. For example, after the patient
takes the generic drug, the amount of drug in the bloodstream is measured. If
the levels of the drug in the bloodstream are the same as the levels found when
the brand name product is used, the generic drug will work the same.<span style="font-size: 11pt;"> </li></ul>
Thankfully I have never had a single problem with generics and have used them for my meds all through the years. I have never noticed a difference in any of the Oxycodone manufacturers and I have used almost all of them! I just ask for what is the cheapest! LOL
Here is the link for people to read:
www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/UnderstandingGenericDrugs/ucm167991.htmPost Edited By Moderator (Blessedx8) : 12/6/2013 4:32:03 PM (GMT-7)