Hi Sherry,
Good question! I'm not a doc, but am in veterinary school & majored in biochemistry, so I understand the pharmacology of these meds pretty well, & I think I can be of some help to you:
Unfortunately, potential side effects of any opioids include nausea, but the medication in the patches is absorbed through an entirely different mechanism than the same medication in pill form, and completely bypasses the stomach/gut, so they have been known to be gentler on the GI tract (although due to the receptors that bind opioid medications, they will still cause slowing of the GI flow/constipation, regardless of the mechanism of absorption).
The patches deliver the medication from your skin directly into your bloodstream, whereas medication in pill form must first be broken down and absorbed through the lining of the stomach or intestine before it can reach the bloodstream. In either case, once the medication reaches the bloodstream, it is then metabolized by the liver, and the resulting metabolites are delivered via the bloodstream to their site of action (in the case of opioids, the mu-opioid receptors in the brain & the intestines).
As for which will work best for you -- definitely something to speak to your doc about
, but with your GI issues, I'm thinking that the patches may be the way to go if you need to be on regular pain control. Honestly, it may end up coming down to trial and error. I know that docs are technically not supposed to prescribe fentanyl patches (don't know about
butrans) to opioid naive patients (patients who were not previously on round-the-clock oral pain control), although we do in the veterinary world -- obviously we just start our patients on a very low dose. Anyways, I think that this would most definitely be worth talking to your doc about
. You may want to talk to both the GI & the surgeon/anesthesiologist (a few days or more prior to surgery is probably best, if possible, especially since when you first start out on a patch, it can take up to 72 hrs to get the meds into your system & notice any benefit, so if they want you to use a patch for post-op pain control, they may actually want you to get started on them
before the surgery). Good luck! Let us know what happens! I'm curious to hear what works best for you!
Skeye
Post Edited (skeye) : 1/9/2013 10:09:14 PM (GMT-7)