Hi All...having Crohn's for 25+ yrs., I run low-grade fevers on a regular basis (in my case, PMS does bring these on). Temperatures nearing 100 & higher, however, would send me running to the doctor (antibiotics are usually needed as Crohn's often causes bacterial infections as opposed to viral). Regarding Sulfasalazine, it's been 20yrs. since I was on that drug (not a big fan of it's abilities). I was on the drug for approx. 3 to 4 yrs. when I started to develop migraines. They were so severe that I stopped the drug & poof!...the migraines never returned.