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Vitamin C

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Crohn's Disease
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Posted 7/2/2008 4:37 AM (GMT 0)

the mention of granuloma (on another post) got me browsing internet and to reading an article on a lady diagnosed with  Malakoplakia an uncommon chronic granulomatous inflammatory disease, not unlike crohns I suppose …anyways …they changed her medicinal regimen from mercaptopurine (was stopped) and “the subsequent management was based on the reliable intracellular penetration of quinolones antibiotics into the macrophages and the hypothetic capability of ascorbic acid of improving the macrophage function by increasing the cyclic guanosine monophosphate”. That’s a mouthful, but noteworthy. I guess I dont hear enough from gastro docs of (natural rememdy) improvement from vitamin C especially for this cycle: Cyclic guanosine monophosphate (cGMP) which deals with regulator of ion channel conductance. It gives me a relationship between granuloma and treatment, albeit not for crohns per se, but the electrolytical approach/correction would seem to me important enough to be mentioned by a doctor for crohns.

I suppose we could answer if vitamin C was beneficial to ourselves, but they should investigate this cgmp thoroughly from the standpoint of ion correction for us, and not just result in drugs for cgmp inhibition.

http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijge/vol5n2/crohn.xml

http://ezinearticles.com/?Vitamins-and-Crohns----How-to-Select-the-Right-Supplements&id=504592

Posted 7/2/2008 3:52 PM (GMT 0)
I hate to tell you, but I did not make any sense out of what you just wrote. It was like Greek to me. (Sorry Athens) Maybe if you wrote this in more layman's terms you might have better understanding of the point you are trying to make.
Posted 7/2/2008 8:28 PM (GMT 0)
I didn't get it either, but, vitamin C in large doses is a natural laxative-I would want to avoid that.
Sj
Posted 7/2/2008 8:36 PM (GMT 0)
I've heard a similar theory which is why I started taking Vitamin C-Calcium Ascorbate which is easy on the gut, it has not caused me any extra issues and along with all the other naturals that I take it likely helps with things.

I take bee propolis, fibre supplements, probiotics, omegas 3-6-9, Vitamin C-Calcium Ascorbate, vitamin A and B12, drink chamomile tea everyday as well and eat extra virgine olive oil everyday too.

:)
Posted 7/4/2008 1:18 AM (GMT 0)

I don't know anything about vitamin C and cgmp, but I have read that vitamin C increases the numbers and efficiency of macrophages.

But what exactly was your point?  I was also puzzled.

Posted 7/4/2008 2:18 AM (GMT 0)
Too much vitamin C can cause issues...although high doses of Vitamin C can protect against cellular damage, 500 mg per day resulted in the increase of oxidative species, 8-oxoadenine and 8-oxoguanine, in an individual’s blood lymphocytes, causing damage to the white blood cells. White blood cells protect against infection in the body. The study suggests while cellular protection is sufficient with 100-200 mg of Vitamin C daily, amounts of 500 mg prove harmful to the body. I was worried because once when I was little I ate a whole bottle of orange flavored vitamin C so I thought that maybe I brought the CD on myself by doing this but I also know that one has to be predisposed to getting IBD in the first place and with my mom having UC that is my connection to getting crohn's (genetics).

I didn't get sick with CD until my early 20's well after eating all those vit C tabs.

:)
Posted 7/4/2008 2:37 AM (GMT 0)

pb4 said...
 The study suggests while cellular protection is sufficient with 100-200 mg of Vitamin C daily, amounts of 500 mg prove harmful to the body.

which study?

Posted 7/4/2008 2:41 AM (GMT 0)
I don't know, I've lost the link to it...some study somewhere I guess LOL!
Posted 7/4/2008 11:21 AM (GMT 0)
dont mix vitamin C with iron

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=340385

what as my point,,,well i was looking at the possible benefits of vitamin C...as far as my goal was..i was looking for a correction to bowel membrane (voltage) from a electrical standpoint, (because we generally leak potassium) and looked at vitamin C, however it has both abilities anti-oxidant and pro-oxidant, so my search continues.

Posted 7/4/2008 11:44 AM (GMT 0)
mabe something more like Fludrocortisone

 

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1411446

Posted 7/4/2008 2:07 PM (GMT 0)
Okay that article about Iron and Vitamin C is interesting. My doc recommended Vitron C an Iron and C combination product when I was anemic and I am still taking it I havent noticed any problems but I think I am now switching to gentle iron.
Sj
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