Posted 12/16/2008 8:00 PM (GMT 0)
You'd think. But let's say- hypothetically- that Kp is responsible for Crohn's. And if somebody goes looking for Kp in the "waste stream" of us Crohnies, they're probably going to find it! The gut flora is going to be completely out of whack, so large numbers of Kp won't be entirely unusual. Even then, it probably doesn't take much in the way of klebsiella to cause these effects; Kp "leverages" itself by sensitizing the immune system. Once the body is sensitized to Kp pullulanase, it's all downhill, letting the body attack itself from the inside out- chewing on the collagen of the intestines (causing Crohn's disease), or the spine (causing ankylosing spondylitis), or the eyes (causing uveitis), or the joints (causing arthritis and arthralgia).
There can be several hundred different organisms in the gut of a healthy individual. This is not diminished substantially in the gut of the ill. Needle-in-a-haystack comes to mind. But Ebringer brings this out very clearly in his work with klebsiella antibodies. It's amazing it's been overlooked this long.