Mine frequently get elevated and will stay that way for a while and then go back down. I've had ERCPs, MCRPs, liver biopsies, etc. done and they only showed that my bile ducts were inflamed. We just keep testing periodically and they always go back down. They thought last time maybe it was the 6mp, but they were elevated before I even started it and the levels went back to normal while I was still on it. Since stopping it, though, my enzymes have been normal.