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Proton pump inhibitors

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Crohn's Disease
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Posted 3/27/2009 8:25 AM (GMT 0)
Does anyone have reflux with their colitis? What do you take for it? I have heard that drugs like nexium can actually contribute to some forms of colitis. Anyone else heard this? Thanks!
Posted 3/27/2009 8:34 AM (GMT 0)
I hadn't heard that...I take omprazole and it works wonders. I do feel a lot better on it.
Posted 3/27/2009 1:33 PM (GMT 0)
Many of us with Crohns also suffer with GERD. I take Prilosec and it works great for me, doesn't affect my Crohns at all. I have never heard of it contributing to any forms of colitis.
Posted 3/27/2009 2:37 PM (GMT 0)
I take Aciphex as needed and it works well. I haven't had any issuse with any worsening of my Crohn's symptoms.
Posted 3/28/2009 12:08 AM (GMT 0)
Thanks, that is good to know. Certainly do not want to do anything to make things any worse.

Posted 3/29/2009 5:33 PM (GMT 0)
When i was in hospital for an emergency resection, they gave me proton pump inhibitors (I had a near-blockage due to several very small strictures, and I guess that caused a backup of stomach acid or something). I can't imagine my GI would prescribe those to me if they could make things worse.
Posted 3/29/2009 9:46 PM (GMT 0)
My GI prescribes me Prevacid. I'd be lost without it. I tried going without it for one week, and it was horrible, lol! Blessings, Julie
Posted 3/30/2009 5:35 AM (GMT 0)
There is a drawback to proton pump inhibitors. They reduce the pH of your stomach acid to levels below what is needed for your digestive enzymes to work properly. This results in incompletely digested food entering the colon and can cause food allergies to develop if the partly digested proteins can pass through a compromised intestinal lining. That result is much less trouble than ongoing acid reflux, which causes immediate and long-term damage, but it is another source of stomach grief. It is also very difficult to stop taking the PPI's if you regularly take a maintenance dose since there is a rebound effect. If you stop taking them, the result is an immediate strong overproduction of acid. It is a bit like being hooked on heroin.
Posted 3/30/2009 11:30 PM (GMT 0)
Forgot to say - suggest to your doctor that you might be better off with an H2 blocker. Those are the older variety of treatment for reflux and basically target the inflammation and not the acid production. If those work for you, you are much better off using them. Particularly for Crohn's, the chances of high gut permeability are up and so food allergy development is likely when taking Proton Pump Inhibitors.
Posted 3/30/2009 11:40 PM (GMT 0)
Thank you, Keeper. I thought I had read similar things before. I don't take it often but it is hard getting off them too. I don't like this class of drugs and it seems to me they could promote problems with bacteria entering the system that do not need to be there.


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