taking tablets - timing?

I know it's probably a very basic question but I'm rubbish at taking any tablets - I am now on Asacol 3 times per day (x800mg) - does it matter if I forget to take the middle one and double up later? does it have to be 8 hours apart? Also does it matter what time of day I take vitamins or probiotics? - I take my thyroid meds every morning after breakfast so can prob handle others then but a potential slavish routine is putting me off getting started (have bought VSL#3)

Thanks

Thanks Gail - I appreciate you replying

Do you also take your probiotics and vitamins etc in the morning as well or do these have to be at different times?

Penny x