I just spoke with my GI about this in my visit yesterday. He always tells people to take it before bed, but I take mine first thing in the morning as that works best for me.
It is important that you do not take anything within 4 hours after it or 1 hour before it. My GI firmly states this to me. I take mine first thing then take my next meds at lunch, then dinner then before bed so none conflict with the hour before and 4 after issue.