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Crohn's Disease
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snohare
Veteran Member
Joined : Oct 2004
Posts : 2088
Posted 6/17/2012 1:58 PM (GMT 0)
Of course it is just one more piece of the puzzle, not the whole answer, but it does make me think about
what happens when these ulcers get going
http://www.newscientist.com/article/dn21919-gut-bugs-confined-to-quarters-by-special-immune-cells.html
gumby44
Veteran Member
Joined : Nov 2007
Posts : 4505
Posted 6/17/2012 3:16 PM (GMT 0)
Thanks for sharing the article. I don't have a science background, so I get confused easily when reading these articles. I can't help but wonder how the immunosuppressant medications like 6MP and the biologics fit in to this picture. It seems like if we are depleting our immune system then the cells that protect against the invading bacteria would be diminished. For my last two major Crohn's flares, my doc put me on Predinsone. The first time around, I ended out with Salmonella, and the second time around I had a major c.difficile infection. It seems like when we try to suppress my immune system to quiet the Crohn's inflammation, it leaves me at risk for not fighting invading bacteria. Anyone, smarter than me on this forum who can enlighten me? ( in layman's terms????)
Singingsupernurse
Regular Member
Joined : May 2012
Posts : 118
Posted 6/18/2012 1:10 AM (GMT 0)
Ok some of these autoimmune diseases(AD) your bodies defenses that fight off germs outside of the body, look at normal germs inside the body,but for some reason they don't see this as "normal". Docs try to use the biologics and immunosuupressant meds to bring your immune system off over drive. This can be difficult, however, b/c sometimes you can lower a person's immunity too much and exactly like gumby44 said it leaves you at risk for opportunistic infections like C.diff. or clostrium difficile. I know, for example, the copaxone I take for my MS mimmics the myelin coating on the nerve cells that the MS "eats" away(copaxone is a biologic med for MS, not use how any of them work for CD). I do know that I can't take biologics for CD....would "turn off" the part of the immune system that causes CD flares...would "turn on" the part of the immune system that would make my MS worse.
Does that make any sense? Have I confused you?
snohare
Veteran Member
Joined : Oct 2004
Posts : 2088
Posted 6/18/2012 1:30 PM (GMT 0)
Beautifully put, Supernurse ! Admittedly I might be a wee bit further up the learning curve, but that was an illuminating explanation to me.
Singingsupernurse
Regular Member
Joined : May 2012
Posts : 118
Posted 6/25/2012 4:10 AM (GMT 0)
thanks Snohare...I just gave up my teaching job at a local college. Not seeing or knowing your audience, you don't know where they are learning wise that is....didn't want to make it too simplistic or over-the -top. Not only am I a nurse, i have CD and MS.
Thanks again
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