My daughter has been using LDN, which keeps symptoms at bay but the labs showed CRP was above normal. So for the last two months she has been on the highest dose of Pentasa combined with the LDN. She just got her lab results Friday and they are incredible.
CRP is now .52. Sed rate is 4. B12 was in the high 600s a month after getting her B12 shot - this never happened before. Because she couldn't seem to absorb B12 orally, she was getting the monthly shots and four weeks after a shot, the B12 would be in the 400s. Because she has no scar tissue, I suspected that, even though she had no symptoms, the small amount of inflammation revealed on the colonoscopy in her terminal ileum was enough to interfere with B12 absorption...typical for Crohn's. So it seemed to me that we would know we had a winner in a med if it managed to restore her ability to absorb B12. Based on the recent results, it seems possible that she can now absorb the oral B12 (which she has been taking all along, even though until now it didn't seem to do much). Her hemoglobin is also normal, at 12.8 though she is taking no iron supplements.
Based on her experience, I think anybody who can't get enough traction from Pentasa alone should consider mixing it with LDN. Spookyhurst did this and it worked for her - she is also on SCD, which she thinks probably helped and maybe it did. My daughter is not on SCD, and the Pentasa/LDN combo has given her no symptoms and for the first time, ever, normal labs and the ability, for the first time in the past few years, to start absorbing B12 again.
The dark shadows under her eyes, chronic for the last few years, are also gone. Is it possible the Pentasa did all of this by itself? In my opinion, yes, possible but not likely given the experience of most Crohn's patients. Even one of her GIs referred to Pentasa as an expensive placebo. We know the LDN does something because when she went off it, her symptoms came back. So for her, we think she has found the winning combo of meds!