Carrier for Crohn's

I was diagnosed with IBD in 9/13. Doctors were unable to tell me if I had Crohn's or UC because I have symptoms of both. I recently had my DNA tested through 23andme and my results show that I am a carrier (CT) for Crohn's (SNP: rs2066844 (C or T) on NOD2 chromosome 16). So does that mean that I more than likely have Crohn's and not UC?

Thanks in advance!

I had similar experience as yours sburg25. I experienced diarrhea, stomach cramps and blood in my stools. I was first diagnosed with UC but it was found later that I'm suffering from Chron's.

This is an interesting question although I am not very familiar about this. After researching, I came up with the idea that Crohn's disease and ulcerative colitis do not affect necessarily the same areas. The article at http://goo.gl/5kIbrw might be helpful.

I think the answer to your question is yes, SNP: rs2066844 (C or T) on NOD2 chromosome 16 is a marker for Crohn's.

I did the 23 and me thing also. I do not understand the results at any level, but just looked at my results and I have the exact same result.

I found the following and think it says yes, but would appreciate any input, as I really do not know anything on this subject, yet I am interested


http://www.nature.com/nature/journal/v411/n6837/abs/411603a0.html


Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of environmental factors in a genetically predisposed host. A gene location in the pericentromeric region of chromosome 16, IBD1, that contributes to susceptibility to Crohn's disease has been established through multiple linkage studies1, 2, 3, 4, 5, 6, but the specific gene(s) has not been identified. NOD2, a gene that encodes a protein with homology to plant disease resistance gene products is located in the peak region of linkage on chromosome 16 (ref. 7). Here we show, by using the transmission disequilibium test and case-control analysis, that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease. Wild-type NOD2 activates nuclear factor NF-kappaB, making it responsive to bacterial lipopolysaccharides; however, this induction was deficient in mutant NOD2. These results implicate NOD2 in susceptibility to Crohn's disease, and suggest a link between an innate immune response to bacterial components and development of disease.

I think that are two questions. One is do you have Crohn's vs. Uc? The other is does the genetic market tell us anything?
I think the answer is (from my limited research and understanding) genetically it seems likely but not for sure until the colonoscopy is done
Dave