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For those with active/recurring Fistula's - Stem Cell Treatment Results

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Crohn's Disease
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Posted 3/10/2016 2:39 AM (GMT 0)
This is encouraging for those dealing with the while fistula nightmare...

Long-term results of adipose-derived stem cell therapy for the treatment of Crohn's fistula:
www.ncbi.nlm.nih.gov/pubmed/25829404

"A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohn's disease, a devastating condition with a high recurrence rate, demonstrated safety and therapeutic potential with a 1-year sustained response. In the present study, 41 of the 43 phase II trial patients were followed for an additional year, regardless of response in the initial year. At 24 months, complete healing was observed in 21 of 26 patients (80.8%) in modified per protocol analysis and 27 of 36 patients (75.0%) in modified intention-to-treat analysis. No adverse events related to ASC administration were observed. Furthermore, complete closure after initial treatment was well-sustained. These results strongly suggest that autologous ASCs may be a novel treatment option for Crohn's fistulae."
Posted 3/10/2016 3:43 AM (GMT 0)
Hmmm, this is interesting. Thank you for sharing it! I thought I had read in another thread that studies showed there wasn't much effectiveness. However, I could be thinking of stem cells to treat Crohn's in general, not for plug/fistula surgeries. This would be so nice if this were to work well.
Posted 3/10/2016 7:50 PM (GMT 0)
The thought of another fistula lingers in the background everyday for me....I hope this research holds out.

I am curious the donor protocol or is it autologous...can't open the article where I am.
Posted 3/10/2016 10:51 PM (GMT 0)
Someone can correct if I am wrong, but I believe they are derived from the left-overs of liposuction... So suck the fat cells outa someone big, mess around with them to get the right cells and inject them in your @ss or wherever.

Fun stuff.

I think it would be soooooo amazing if people could find relief or at least have a 70%+ chance of healing this way versus going through the whole surgery and drain/plug thing. Perhaps it's worth keeping an eye on and seeing if there are more trials. I'd do this, or try it as I have one that opens from time to time depending on IBS/foods I eat. It's a complex fistula.
Posted 3/13/2016 12:44 AM (GMT 0)
This sounds AMAZING. I wonder if it would have to be donor cells or if they could harvested from the actual patient if a non-Crohn's sufferer? Interesting trial.
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