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Has anyone had success with something else after Humira stopped working?

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Posted 1/27/2018 4:43 AM (GMT 0)
I've been on Humira (every other week) for about 2 months now. After about 2.5 weeks I started to feel almost symptom free. That sadly only lasted about 2 weeks and then the symptoms came back.

After about 4 weeks my doctor did some blood tests that showed that I had begun to develop antibodies to Humira.

At about 6 weeks on Humira my doctor had me add methotrexate to the shot. I've been on Humira and Methotrexate for about 2 weeks now and I still haven't noticed a difference in my symptoms.

I'm still on Methotrexate and Humira but I don't have much hope that it's going to work.

What I'm wondering is if another biologic is likely to work for me after I developed a resistance to Humira so quickly? Is there anyone out there who developed a resistance to Humira so quickly but then went on to have long term success on a different biologic like Remicade or Simponi or something else? Or is it likely that I will just burn through the other biologics just as fast as Humira? I guess I'm just looking for hope that something else will be my miracle drug as it's not looking great for Humira right now.
Posted 1/27/2018 6:06 AM (GMT 0)
Yes definitely a good chance you will have better results with another one but I would talk to your doctor about starting the next medication in combination with another drug so that it prevents antibodies in the first place. not everyone is the same but it's definitely not time to lose hope! If you had some good experience with humira, remicade with something like the methotrexate or 6mp might be good to think about. I was on humira but developed sideffects after a few months. I was eventually switched to remicade and my doctor prescribed a low dose of the 6mp to prevent antibodies. So far so good 2 years later.
Posted 1/27/2018 3:21 PM (GMT 0)
Thanks Labradorite. Hopefully maybe I'll try Remicade next.
Posted 1/27/2018 7:58 PM (GMT 0)
I was on Humira for nine months and it did nothing for me. Have been on Remicade for six months now and it seems to be working. I still have some symptoms (stomach pain, fatigue, and joint pain) but it is much better than before, so I would definitely give Remicade a try.
Posted 1/27/2018 9:17 PM (GMT 0)
I have been on Remicade after Humira for about 2 years now and the difference is remarkable. Remicade has given me part of my life back. My GI also has me on Imuran. While it doesn't work for everybody, it is worth a try for you.
Posted 1/31/2018 8:24 PM (GMT 0)
In 2007 I was diagnosed with CD in my colon after having two massive fistulas and explosive D and pain in my side. GI insisted I go on humera or I will loose all my colon and be on a bag. I did my research and opted to get another GI more conservative and to try the SCD diet.

I changed my diet 100% to follow the SCD with fanatical dedication and after 7 months, both my fistulas were healed, I has no more D or pain , and I felt great. Three years later after no symptoms I had a colonoscopy and they found absolutely no active signs of CD in my colon or intestine. Last year I had another colonoscopy and again , no signs of anything. It was as if I had never had CD. The doc said the only thing he saw was some scar tissue from my fistulas, but nothing else.

To this day I still follow the SCD diet, but not as strict as in the beginning. I am 67 and besides curing my CD, the diet has helped me in other ways too. My cholesterol is 179, triglycerides are 80, blood pressure is 115 /69 and I take no pills for anything.

Research the diet, if nothing else is working, what do you have to loose.
Posted 2/1/2018 2:59 AM (GMT 0)
I have been on Humira for 11 weeks and am stuck on 5mg of prednisone. I still have mild symptoms here and there (while on prednisone) and when I tried to stop the prednisone symptoms started to return. My doc wants to do a colonoscopy and try another medication if he sees inflammation. I am starting the SCD diet and Acupuncture. I am not going to stop my meds but I think this may be what I need to get me off of the prednisone. I am sick of all of these toxic drugs.

NY-Sooner - did you tolerate the yogurt right away?
Posted 2/1/2018 2:55 PM (GMT 0)
I'm currently and successfully on Entyvio now. At some point Humira just stopped working for me so I was switched to Entyvio. It took a good 4 months for me to notice any changes but as of my last scope I'm considered as being in endoscopic remission.
Posted 2/1/2018 3:19 PM (GMT 0)
I had no problems with the yogurt. Matter of fact, the yogurt is the critical point of this diet since it replenishes all the bad bacteria in your gut that you starve to death with the diet, it replenishes it with good bacteria. Some people say you can substitute probiotic supplements, but you would have to take 20 pills a day to equal what you get in one cup of yogurt.

I made my own yogurt since store bought is not fermented long enough to eliminate all the lactose and natural sugars in the milk.

When I first started, I would eat two cups a day that I would mix with cooked apples and cinimum.

Now I only have one cup of yogurt every day that I mix in a smoothie with blue berries, black berries, some spinach, banana and some honey.
Posted 2/4/2018 10:54 PM (GMT 0)
I had a severe reaction to Humira. The started Simponi and had great success with it for 9.5 years.
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