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Antibiotic induced diarrhea

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Crohn's Disease
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Posted 6/10/2023 3:42 AM (GMT 0)
After my resection surgery, I would like to get on Biologics treatment such as Remicade or Humira. To do that I need to have my latent TB treated first. Yesterday I saw an infectious disease specialist and started 4-month Rifampin treatment on the same day. Within a a few hours of taking Rifampin, I noticed my urine turned into red/orange color, which was expected.

Today I started have bloody diarrhea. I had to go to the bathroom every hour, which surprised me. I called the infectious disease specialist, who told me that red color in my stool is probably from the Rifampin (not blood). And he asked me to resume Rifampin in a few days after the diarrhea stops. It is extremely rare for me to have this kind of diarrhea, let alone bloody ones. For the past 10-20 years, my primary symptoms from Crohn's is abdominal pain caused by multiple strictures.

It looks like I will not go back to Rifampin. It is unfortunate, because I heard a lot of positive stores from using biologics. I just cannot do it with latent TB untreated. I may need to rely on my Chinese herbs for treatment.
Posted 6/12/2023 10:43 PM (GMT 0)
This post really showed me how difficult this disease is and how much it impacts parts of our lives that others don't have to worry about.

I'm sorry that you are going thru this. I hope you find a solution.

Clo
Posted 6/20/2023 1:12 PM (GMT 0)
Even healthy people get bad diarrhea on antibiotics. Are you taking a probiotic? I would do Florastor at least 4x a day if I were you. It should help.
Posted 6/20/2023 4:00 PM (GMT 0)
No, I am not taking probiotic. On the day I had bloody diarrhea, I took a stool iFOBT test, which came back Positive. I immediately stopped Rifampin, and the diarrhea stopped the next day. But the black stools continued for a week (indicating possible continued intestinal bleeding). For the past four days, my stool color has finally become normal, which I believe the bleeding has finally stopped. Rifampin is like a knife, which cut through my intestines causing my hematocrit to drop from 32.4% to 26.3%, Hgb from 10.1 g/dL to 8.5g/dL in about a week. Just one dose of Rifampin caused massive blood loss. I am thinking of getting an iron infusion to help anemia. 20 years ago, I took iron pills, which hurt my stomach badly.
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