They are driving me crazy too. Here's my theory: I only have them when I'm in a flare. I usually bleed when I flare. I think that my colon leaks into my blood system, thereby enabling toxins (or crap!) to travel throughout my body, which explains the joint/muscle pain at times, and the night sweats are my body's way of cleaning out those toxins. It has to be Crohn's related, because it only happens when I'm flaring and if I bled alot that day, I'm drenched at night. I have to change pajamas 2 or 3 times and I also lay a towel down to sleep on, which also gets wet. Does this make any sense to anyone? I only take LDN, no meds for Crohn's.