Do more meds make you feel worse?

Yup! I have an appointment with my Crohns specialist on Monday and since I just had a resection a couple weeks ago and have no real need for meds at this exact moment in terms of keeping things under control, I'm going to ask him if we can discontinue all of my meds (minus the prednisone obviously since I have to taper off that), see how I feel then slowly add them back in to see exactly the ones I need and which ones are giving me side effects (being tired, depressed, ect...) Im not sure how hes going to feel about that, but I honestly feel like crap at the moment and I want to know why or whats causing it.  Im just sick of being on meds and not knowing what they are all doing to me, I was thrown every drug under the sun during my last flare up and I got all screwed up and havent been the same since, so I honestly think getting off all off them, and letting my body do what it needs to do...flare or not...then slowly and one by one add the meds back to see whats going to work. ~sigh~ Why does this disease need to be so complicated.

I am in complete agreement. More meds are always worse for me. And Mj8 - the 6mp had the most negative "systemic" effects on me. I was depressed, fatigued... and just generally crap-tastic. If you're looking to point fingers at one of your meds - I would put that one FIRST on the re-introduction list.

I would give the Asacol a chance to see if that works for you. Its the only Crohns med I take and seems to work well for me:) And it is one of the mildest ones out there. Good luck!

Initially yes. When I started the pentasa and alinia my symptoms actually got worse and I started losing more blood. After prolonged use though I began to feel better. I'm wondering if meds do that with the pattern of something having to be much worse before it gets better. I do notice a lot of fatigue still though. And cramping in places like my feet...