Zosyn and Flucanozole

I am in a flare and have one big abscess and a few smaller ones. Apparently, they put me on Zosyn and Flucanozole to treat the abscess. One of these drugs has stopped the bleeding I have had for everyday for 15 months. Not sure which one. However, I am really, really tired. I want to sleep and rest all day. When I go to sleep around 12:00 AM, I wake up 2-3 times every 2 hours or so to have a bowel movement. I do not get much sleep. So, during the day, I have to sleep. However, I still get some blood from my hemorrhoids sometimes. Today I had one BM with quite a bit of blood loss. I am anemic. My white blood cell count is around 10.3 usually, but it dropped all the way to 7 during the hospital stay. Who knows what it is now. I have not been very tired usually like I am today.

I am wondering now what is making me so tired. Lack of sleep? Zosyn? Flucanozole? Blood loss? Anyone have any input on this?

In July 2006 "just in case" my daughter had a bacterial infection, the GI at the hospital ordered Zosyn for her - it made her Crohn's symptoms worse, resulting in cramping. Perhaps your docs should consider meds that help the abscess, but are not problematic for Crohn's. Flagyl and Cipro can, for instance, be used to try to treat an abcess without making Crohn's worse.  

There is a slight potential for an adverse drug interaction between fluconazole and Entocort:

"Fluconazole may block the breakdown of budesonide by the liver. If this happens, blood levels of budesonide could be increased. This may cause an increase in both the intended effect and the side effects of budesonide, including stomach irritation, facial swelling, and mood changes. If these drugs are used together, your doctor may want to monitor you closely for side effects and adjust the dose of budesonide if needed.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems."

http://www.drugdigest.org/wps/portal/!ut/p/c1/fY3dEkJQFIWfxRPsHfm7lAYHB1MUbowaI8UhDJOnjweote7WzLc-SGEty6eqzMeqZXkNMaRSJqCJaOokQoMISBSLKq52WtcdXDdCyvBHNATPapsCEkjlnz8KDxfW9s3mm6pihhBi3GfnJ3bUHRhdVD8IqUjCu8wv-mi7iUMMfzjayehG5YRkCZaoJr1q0fHziA7xzXPeGset1uSvtXuxeY5F7QsKuZeN/dl2/d1/L0lJZ2tsZyEhL3dIRUJKRXRRQmxBIS9ZSTU0NTAtdy83XzMwRzAwR0NJVTBGSTMwSThITThMQVIzMDgy/?drugList=550830&cD=550830&cD=266&dN=Entocort+EC+Capsules%5EFluconazole+Tablets%5E&step=check&CheckFDA=1

 

Post Edited (njmom) : 9/15/2009 6:36:00 PM (GMT-6)

njmom said...
In July 2006 "just in case" my daughter had a bacterial infection, the GI at the hospital ordered Zosyn for her - it made her Crohn's symptoms worse, resulting in cramping. Perhaps your docs should consider meds that help the abscess, but are not problematic for Crohn's. Flagyl and Cipro can, for instance, be used to try to treat an abcess without making Crohn's worse.

There is a slight potential for an adverse drug interaction between fluconazole and Entocort:

"Fluconazole may block the breakdown of budesonide by the liver. If this happens, blood levels of budesonide could be increased. This may cause an increase in both the intended effect and the side effects of budesonide, including stomach irritation, facial swelling, and mood changes. If these drugs are used together, your doctor may want to monitor you closely for side effects and adjust the dose of budesonide if needed.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems."

http://www.drugdigest.org/wps/portal/!ut/p/c1/fY3dEkJQFIWfxRPsHfm7lAYHB1MUbowaI8UhDJOnjweote7WzLc-SGEty6eqzMeqZXkNMaRSJqCJaOokQoMISBSLKq52WtcdXDdCyvBHNATPapsCEkjlnz8KDxfW9s3mm6pihhBi3GfnJ3bUHRhdVD8IqUjCu8wv-mi7iUMMfzjayehG5YRkCZaoJr1q0fHziA7xzXPeGset1uSvtXuxeY5F7QsKuZeN/dl2/d1/L0lJZ2tsZyEhL3dIRUJKRXRRQmxBIS9ZSTU0NTAtdy83XzMwRzAwR0NJVTBGSTMwSThITThMQVIzMDgy/?drugList=550830&cD=550830&cD=266&dN=Entocort+EC+Capsules%5EFluconazole+Tablets%5E&step=check&CheckFDA=1




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At first, the doctor in the ER put me on IV flagyl and cipro. I told him that I got Crohn's/UC after I used cipro, but he still put me on it. Then, the colo-rectal surgeon took me off cipro. When the Zosyn started is something I do not remember. They took me off Asacol and Entocort in the hospital. After a few days my stomach hurt really had. After I was put back on them, I felt better. I am pretty sure that Zosyn is causing me diarrhea. If not Zosyn, then it is the flucanozole. One of these is also making me have more a lot more bowel movements.

I just recently got the medical records from the hospital, and one of the abscesses I have was 6.2cm by 2cm or so. That is pretty big. The smaller ones were around 2x2cm. The thing that is getting me mad is that the colonoscopy I had last year stated that I had crypt abscesses, but my GI did not do anything about it or even tell me. I only found out about 4 months later when I went to another doctor and she asked what I had done about the abscesses.

The thing that stinks is that if I have the CT scan next Monday and it is still there, it is surgery. The colorectal surgeon said that he would remove the diseased part of the colon. I am not sure if he meant the part with the abscesses or the part that has the crohn's/UC. It seems like surgery will be the best option to prevent cancer, because I was told that I will die from cancer anyway because my testicle would not descend when I was around 2 or 3.