My son gets Benedryl (and other premeds) through the IV before he gets his Remicade infusion. But he gets his infusion in a pediatric infusion center, so maybe that is different. Good luck to you. Remicade has been a lifesaver for us.
Take care,
Nancy (son Ben, 15, CD dx 3/06; double Remicade every 6 weeks, Lialda, Probiotic)