Sniper, my husband has been giving me methotrexate injections in the stomach for over two years. Like you say, very small needle and sometimes don't even feel it. Every once in awhile I wake up with a big bruise. Could be hitting a blood vessel and a few times there is a little drop of blood. Sometimes I have matching bruises on either side. I am older and seem to bruise quite easily these days. I don't worry about
it.