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Which one of the 5 ASA is supposed to target the terminal ileum?

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Crohn's Disease
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Posted 3/27/2011 2:42 AM (GMT 0)
My  doctor has  me on lialda.  I thought that was mainly for UC and I don't have  any colon involvement at this time.  All my CD is located at the terminal ileum.  Am I on the right asa for that?  I want to exhaust all of my asa options before going to the heavier meds. 
Posted 3/27/2011 4:15 AM (GMT 0)
I switched from Asacol to Pentasa six years ago for that very reason. It was a good decision for me.
Posted 3/27/2011 10:29 AM (GMT 0)
I wish I knew the answer. I have crohn's colitis. So far I have been on lialda for almost two years. GI switched me to apriso a week ago. I wanted to try asacol but couldn't get the gi to agree. From my reading, seems like asacol would fit the bill. apriso is for people with uc who are in remission--not me. gi says it has other uses.
I, too, want to try all the 5-asa drugs before hitting any big guns.
Good luck.
Posted 3/27/2011 2:56 PM (GMT 0)

some gi's want to attack it aggressively, nip it in the bud, so to speak.everything depends on severity of cd. JMHO, would be to attack it with strength, then back off once you have contained it a bit. or have it settled down.

AG

Posted 3/27/2011 3:01 PM (GMT 0)
I have Crohns in the most common area the TI/Cecum area. I used to use Pentasa, but it gave me alot of bloating and more diarrhea. Switched to Asacol and have been successfully maintained with just Asacol for almost 6 years. So even though they say Pentasa is for the TI area, Asacol also works in the same area. Good luck!
Posted 3/28/2011 4:51 PM (GMT 0)

There is no firm guideline for how to treat Crohn's with any particular ASA. Pentasa tends to release mainly throughout the entire small intestine, while Asacol tends to start to release in the terminal ileum, and then continuing mainly throughout the colon.

My daughter has Crohn's confined mainly to the terminal ileum, so theoretically, either Pentasa or Asacol could treat it. She tolerated the Pentasa well, but the Asacol left a very bad taste in her mouth. She plans to try Pentasa again, some day soon, because she didn't have a chance to try it again to see how well it worked.

Lialda, like any 5 ASA, is intended mainly to treat UC but it's really a toss up which ASA can help your Crohn's. At least it is just a once a day dose, so if it works, great! This stuff is all trial and error...

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