Thanks for the responses everyone, I really appreciate it.
I've been speaking with my specialist's nurse and I have asked a few times if they know what is causing it - at this stage they don't, which doesn't feel right to me, I want to know the cause of the strange low levels.
Hopefully they come up with some answers... I don't believe I am allergic to the remicade as I've had another infusion since the puffiness began... some days I wake up puffier than others, its a mystery...