Entyvio 12 weeks - still not working

Hi guys, has anyone been on Entyvio and waited over 12 weeks for it to work? My Crohn's nurse has said it can take up to 14 weeks, give it time etc but was just wondering if anyone had experience of it taking a looooong time and then working brilliantly. Trying to stay optimistic, was on Humira for 9 years and hoping it wasn't a bad move to come off it and move onto Entyvio. Thanks!

12 weeks - I will assume 3 loading dose and 1 maintenance dose = 4 doses ?

I went through the same thing, I was told repeatedly that Entyvio is slow, be patient, wait until 5 doses.

I had absolutely no changes, went through 4, 5, nothing. My doctor referred me to a researcher in Cedars which took months to set up, by then I went through 7 infusions. NOTHING.

Moral of this story for me: The very reason behind a loading dose of 3 is to shock Crohns in its tracks. My opinion is that by dose 4 you should start seeing SOME CHANGE ( reduced diarreah, less distention, less pain) and by dose 5 and 6 you should definitely see major changes, if not then you should seriously consider stopping it. The GI office of 4 GIs have 15 Entyvio patients, 10 it worked, 5 like me it did not work at all.

So then I was switched to Remicade and Imuran, I was at 5 mg and by the 4th dose nothing. I was not going through that anymore, so the doctor doubled the dose to 10 mg and started improving. By now I am at my 6th infusion and have been improving.

As many of you know by now, Stelara has been approved for Crohns by the FDA. This is a remarkable drug where I did respond by injection 3. See my posts on Stelara, that will be my next stop.

Thanks everyone. I'm about to have my fifth dose in two weeks time. I responded well to both previous biologics (Remicade three years & Humira nine, with maybe 4 brilliant years then a gradual loss of response). I think there is an option to go onto Stelera if the Entyvio fails. Will see how I feel in two weeks time when I will be at wk 14.