humira pregnancy?

Welcome to the forum, congratulations!

I haven't been on Humira, but I've had two pregnancies with Remicade, which is a very similar drug. With both pregnancies (done across three different states with three different sets of OBs and high-risk OBs) the consensus is that it's best to stay on the medication the entire pregnancy. It does get into the baby a bit, but it doesn't cause any harm. The baby will be born with a small amount of the medication in their system, but as long as you keep the baby away from the public for a couple of months (which you should kind of do anyway), and don't do any live vaccines for the first year (which in the US is only the rota-virus), then you should be just fine. And since Humira doesn't stay in the system as long as Remicade, I imagine that it's even safer. The study he referred to for all of this is the PIANO study, I believe is what it's called.

My GI mentioned to me that Entyvio (I *think* that's the medication he said) doesn't cross the placental barrier at all, so it should be even better if you want to switch to it. I was already about 5 months along with my second, so I didn't feel comfortable switching in case it didn't work or I flared or something while pregnant.

Also, with regards to breastmilk, the proteins for Remicade (and I am assuming Humira) are too large to get into breastmilk, so it's completely safe to nurse/pump after childbirth.

Here's a couple links that talk about biologics and pregnancy. Generally, you would be fine, as many moms have had happy and healthy babies despite being on biologics (humira, remicade, etc.).

From conception to delivery: Managing the pregnant inflammatory bowel disease patient
www.ncbi.nlm.nih.gov/pmc/articles/PMC3974516/

The Second European Evidenced-Based Consensus on Reproduction and Pregnancy in Inflammatory Bowel Disease
ecco-jcc.oxfordjournals.org/content/eccojc/9/2/107.full.pdf