Definiately weight gain for me. Been on Remicade almost 3 years, I exercise and watch what I eat, but gained a good 20 pounds. But, I would rather have the extra 20 and be able to leave the house and function, so it's worth it. I couldn't function with constant diahrea. My doctor says it's not from Remicade or Methotrexate, but I'm pretty sure it is.