deplin and saphris?!

I work with Deplin and I will try to address your question. Deplin is a Prescribed form of the folic acid converted, L-methylfolate, which actually crosses the blood brain barrier (folic acid does not) and this L-methylfolate helps in creating more of the three neurotranmitters. The three neurotransmitters are believed to have something to do with depression, hence the success of SNRIs and SSRIs. Since Deplin is as safe as a vitamin (see Deplin website) you may not have to concern yourself with side effects which may lead to noncompliance. I am not familiar with the other product but if you are depressed, Deplin may help but its indication is an augmentation agent. Let me know if you may have any more questions.

Deplin (or L-metholfolate) is very beneficial for those who have an inherited inability to metabolize folate from folic acid. Genetic testing is required to determine that, but your physician has prescribed it hoping to see its good effects without the necessity to do genetic testing.

If you have the inability to metabolize folate from folic acid, L-methylfolate is superior to any med I've taken. I would not be without it.

It generally takes two weeks or more to see the effective benefits from it; however, you may begin to feel much more content and happy within days if you do have an inability to convert folic acid into folate (which is the only form the brain can use and it needs folate).

I hope you find it very helpful.

I.G.

Hello, Texassaphire,

You would not be aware if your brain does not receive folate from the blood stream unless you have genetic testing.

Doctors are often trying to find the best combination of medications to help the patient to wellness. The use of L-methylfolate is one medication that can cross the blood-brain barrier, so your doctor is hoping that perhaps you might be able to benefit from an increase in folate in the brain (which increases three neurotransmitters: serotonin, dopamine, and norepinephrine all involved in better feeling tone).

It may work, and it may not work for you, just as certain other medications you've taken over the years may have worked or may not have worked. It's your doctor's effort to find the right thing for you.

I.G.