How do you know if you are going through menopause and need hormones or if you are just plain depressed and need anti depressants? I have been on anti-depressants for over 12 years, for my horrible moodiness. I have been on all of them. Not one works better than the other, but does seem to take the "edge" off. I had a TAH 2 years ago, which left me with one ovary. I no longer have periods, but I do experience the pms still. Anyone have any advise?